Intrinsic cell factors are essential regulating tissue organization; however, understanding extrinsic cells constituents (extra cellular matrix, ECM) and its interface are critical issues regarding early restoring of functional tissues.

In general, our materials attempt to restore connective tissues where damage, weakness or loose exist. The different devices stimulate the migration, seed and proliferation of functional tissues. Over a period of time, at implant sites, the implants will be biodegraded without impaired function or immune rejection, taking the texture and appearance of normal host tissues.

Aongen™ Collagen Matrix is a 3-D scaffold resulted from applying tissue engineering technology. Aongen™ Collagen Matrix contains a connected porous structure made of cross- link ≥90% lyophilized porcine type I atelocollagen and ≤10% chondrotin 6-sulfate (glycosaminoglycan, GAG)

Our implant material functions as a scaffold for cellular invasion and capillary growth due to its chemotactics and adhesion properties. Its porous and connected structure is a stable soft skeleton which tolerates adequately protease activity, providing sufficient volume for cells to attach, grow randomly, and synthesize their own macromolecules. (Fig. 1)

Tissue ingrowths occurred first in the periphery and proceeded toward the center, accompanied by implant absorption. The biocompatibility observed is evident by the lack of adverse, inflammatory or immune rejection due in part our products do not contain antigenic telopeptides and show adequate protease resistance activity.

Coming pipelines include develops in ocular implants, long lasting biodegradable matrices and drug delivery compounds.